Why AlexSys ?
The last decade has provided access to a large amount of data resulting from high throughput genomic technologies, such as transcriptomics, proteomics or interactomics. This wealth of data now means that it is possible to perform detailed studies of the complex molecular networks implicated in the essential processes of life. A critical step in these studies is the comprehension of the evolutionary processes involved (duplication, loss, recombination), since they determine the sequence, structure and function of macromolecules, and finally, the biological complexity of organisms.
Architecture
UIMA
The AlexSys expert system is designed around a central core, containing the main data processing and alignment construction components. The information that drives the decisions made within the system is stored in a separate metadata layer. Finally, a knowledge base layer contains the necessary background information for the selection of the most appropriate aligner(s), based on the input data.
Knowledge based system
The knowledge base in AlexSys contains ‘alignment models’ that are used to predict the strengths and weaknesses of the individual aligners, given a specific set of input sequences. To achieve this, a supervised learning or classification algorithm is used
Contact Us
- Address
- IGBMC-Laboratoire de Bioinformatique et de Génomique Intégrative, 1 Rue Laurent Fries, 67404 Illkirch Graffenstaden, Strasbourg, France
- aniba@igbmc.fr